Human aging is an extremely complex biological process that has been explored and studied but still lacks a comprehensive understanding of its mechanisms. The transcriptome is a major determinant of age-related phenotypic diversity, and therefore a systematic analysis of the aging transcriptome can help researchers discover and enrich the mechanisms of molecular changes in aging.

Introduction to Aging Transcriptome Research

Systematic studies of gene expression changes help us to understand the different age-related interacting processes, which can serve as biomarkers or even predictors of aging. However, this does not represent a comprehensive molecular mechanism of aging, and if aided by studies of the aging transcriptome, it can help to elucidate age-related change pathways and specific responses.

For this purpose, we have to collect mRNA expression data by sequencing technology as well as to fully understand the specific roles of different RNAs, including ncRNAs, miRNAs, circRNAs, tRNAs, and so on, to explore their specific roles in cellular function, gene expression, and so on in aging.