Recombinant protein expression in CHO cells is an important aspect of synthetic biology that has revolutionized the pharmaceutical industry. Therapeutic proteins require proper folding and post-translational modifications to be effective and biologically active. CHO cells are the most frequently used host for commercial production of therapeutic proteins due to their ability to perform these modifications. However, an unpredictable decrease in protein productivity during the time required for scale-up impairs process yields, time, finance, and regulatory approval for the desired product. Therefore, it is important to assess cell lines at stages throughout the period of long-term culture in terms of productivity and various molecular parameters including plasmid and mRNA copy numbers and location of the plasmid on the host cell chromosome.

At CD Biosynsis, we offer services for improving the stability of CHO cells and enhancing recombinant protein expression. Our services are designed to address the challenges faced by the pharmaceutical industry during the production of therapeutic proteins.

Figure 1: CHO Cell Community Effort Toward Better Biopharmaceutical Production Costs. (Harcum S. W., Lee K. H. 2016)

Learn more：Recombinant Protein Expression in CHO Cells