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Sciatica pain can be debilitating, but some strategies may provide immediate relief for sciatica pain: Rest in a comfortable position. Apply a cold or hot pack to the affected area. Gently stretch or do exercises that can relieve pressure on the sciatic nerve. Over-the-counter pain relievers or anti-inflammatories may help (follow recommended dosages). If pain continues or worsens, consult a healthcare professional for a thorough evaluation and treatment plan, which may include physical therapy or medications.